The only thing was when it booted, it booted into safe mode DRSM no matter what I chose in the windows boot menu.
Soltution:
I logged in as the local administrator on the server (DRSM account?), run msconfig, and uncheked the "Safe boot - Active Directory Repair" ticket.
Then the server boot fast and everyting is fast and snappy

by the way, which backup method does endpoint backup use? Reverse Incremental or forever incremental?
We are using a file lever off-copy solution until the remote repository is coming in the final release, so if the full backup file is changed regulary we have to take a closer look until then.