No changes in guidance after installing U2. In fact, there has not been any changes a few years now, and I don't expect any changes in the foreseeable future.
As the reminder, in early B&R versions, technical reasons for running active full where:
1. To defragment and clean up full backup file from stale data. This need has been addressed by the addition of Compact functionality, just make sure you have it scheduled to run periodically in the advanced job settings.
2. To "break" incremental backup chain periodically for perceived added reliability. This need has been addressed by the addition of Health Check functionality. Again, just make sure you have it scheduled.
So, there are no reasons except peace of mind. Most importantly, just remember to test your customer's backups (whether or not you end up using active full).