Don't mismatch compression setings (dedupe friendly) and dedupe settings (storage optimization).
Using StoreEasy (windows 2012r2), I would recommend not using compression and using LAN storage optimization if you plan to export the backup files to tapes (to maintain a reduced vbk and thus reduce tapes needs). If not exporting to tape you can disable dedupe at veeam level or set it to large file 16TB+.
You could also leverage the new repository setting in v9 ti allow per VM backup file.
Remember to do an active full to apply new dedupe settings.
Veeamizing your IT since 2009/ Vanguard 2015,2016,2017