If I understood your setup correctly, you would want something like this. I am not great at diagram drawing, but hopefully it is clear enough.
You may also want to have a few virtual proxies on the hypervisor VMs for Hot-add operations (i.e. target write for replication if you plan to do on-site Veeam replication; replica disks cannot be written in Direct-SAN mode).
Of course that's just a generic picture, so if you have a specific setup in mind, please share.
And it goes without saying, you would want a connection with necessary ports open between VMware
and 2nd host
, to be able to restore from DR Repository to production in case your 1st host is temporarily unavailable.