One of the best backup+replica scenarios is backup+backup copy+replica from backup files
. Doing that you take a snapshot of the source VM only once and transfer data between sites only once, at the same time you will meet 3-2-1 rule, having backup+copy of the backup offsite+replica VM.
Regarding restore, in a case your source site shut down, you make Failover
to the replicated VM. Then you have a choice either to perform a permanent failover
and make replica VM a production one or failback
to the source site. It will let you have minimal RTO. In a case replica is not usable, like BSOD, hack etc. you can restore from backup. That`s why it`s recommended to have VBR server in the DR site, to be protected in a case of disaster in the production site.