I, too, would love to see "Exclude VM(s) from this SureBackup job" added as a feature.
It has been mentioned a few times that you have to do manual effort either way. In my case, I have a variable number of VMs in a backup job (it changes overtime) and one CONSTANT member of the group that should be excluded. The manual effort to create application groups would be endless effort. The manual effort to exclude a single VM, once, would be an exceedingly small and finite effort.
Because of this, I have a job that runs that has 1 failed VM every night and the rest succeed. At this point, I'll just deal with it, it lets me know the SureBackup job runs, but it is really annoying.