My new solution is to have local copies for fast restores but also replicate to offsite dtacentre and then these replica backup to tape as a third backup too.
Have a quick read of this -:http://www.veeam.com/blog/how-to-follow ... ation.html
There are many ways to implement the solution but multiple copies are the way forward as above, and recovery time your business is willing to cope with should be the main driver . e.g. if you link goes down and you are relying on the remote site for data recovery you could be left exposed.