I am glad to hear you are looking into Veeam Endpoint Backup as a potential solution.
How will it handle this. Will it queue them up so it does not get overloaded?
Veeam B&R repository's load control settings
affect the VEB jobs, so you can throttle VEBs activities by setting the ‘Limit maximum concurrent tasks’ and ‘Limit read and write data rates’ to the desired values.
Will they benefit from de-duplication on the repository?
Definitely, since you are backing up the same operating systems.
What are the best practices to limit cryto-malware risks.
might help you.