Just start playing with agent and configuration.
Found that Agent does not support windows variables (or at least that one, i'm interested on).
In our environment the users have a base workstation, as well they are moving across of departments.
It creates multiple User Profile's folder on each computer, but that folders not needs to be backed up.
Only the current user profile needs to be backed up.
We currently using Symantec DLO and we can set to backup only %CURRENTUSERPROFILE%\.
This functionality I cannot find in Veeam agent, but it will be great to have that option.
So we can reduce the backup size, that needs to be stored.