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the sort question would be as usual "it depends"...
In reality, you first need to understood with some tests the time it takes for a single incremental run to complete. Those 40 Gb are the daily changes produces by your VMs, the total size of the replica, or something else?
Also, you (or your management) is in charge of defining the desired RPO, and from there do some calculations on data to be moved and available bandwidth to find out if it is ok at the actual level, or it needs to be increased.
Latency is not a huge problem for replication, since it is asynchronous, I would be more converned about link resiliency and bandwidth.
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