I'm assuming since you state you are mobile often, do you use an exchange edge server of some kind besides active sync? or behind a VPN in these cases?
In my place generally mailboxes are quota-ed low and users barely work remotely, when they do it is over a VPN, so no edge services (besides what we have setup for active-sync for mobile phones).
This is why usually disabling cache mode hasn't been a huge issue, since we our users usually have amazing bandwidth.
Oh of course, I love Veeam! Best Backup product I've ever used. I'm amazed they still have "On-Demand Sandbox"... really just a sure backup job, but I found with a setup that requires a fair amount of dependent servers (I.E SharePoint) even with a decent vPowerNFS store startup times and performance take a huge hit.