There are actually many possibilities. Veeam B&R is composed out of different components. For example, we have the B&R server (some call this the command and control
), we have proxies, gateway server, repository, WAN accelerator and so on...
You could do the backup and/or replication directly to the data center location but that means that all the data will go over the WAN. Depending on the situation, you might want to consider WAN accelerators in between, or do a backup to a local repository (at that site) first and a Backup Copy JOB to the data center location (offsite) after business hours.
As stated, it is possible with one single server and backup destination, but then I suggest you look at the timing and maybe even add throttling so it doesn't steal all the bandwidth.
Personally I would consider adding a VM on each host in a location and backup first to there (will also speed the restore up as the latest data is "at location") and then a Backup copy job after business hours to the datacenter for having an offsite backup
My 2 cents